Do interleukin-6, hyaluronan, soluble intercellular adhesion molecule-1 and cancer antigen 125 in dialysate predict changes in peritoneal function? A 1-year follow-up study

Scand J Urol Nephrol. 2005;39(5):410-6. doi: 10.1080/00365590500386809.


Objective: Diminishing ultrafiltration and dialysis adequacy may limit the long-term use of peritoneal dialysis (PD). Inflammation may play a role in changes in peritoneal function. This study was designed to evaluate alterations in peritoneal function and soluble factors in dialysate during a 1-year follow-up period.

Material and methods: A personal dialysis capacity test was performed at the start of the study and after 6 and 12 months in 20 patients in order to determine dialysis adequacy and membrane characteristics. Dialysate was collected during the test days for analyses of interleukin-6 (IL-6), soluble intercellular adhesion molecule-1, hyaluronan and cancer antigen 125 (CA125).

Results: There were no significant changes in dialysis adequacy or membrane characteristics during the 1-year follow-up period. The appearance rate of IL-6 in dialysate increased significantly (419.8+/-63.3 at the start, 784.1+/-136.4 after 6 months and 1149.3+/-252.2 ng/24 h after 12 months; p=0.006) during follow-up. Furthermore, the appearance rate of CA125 increased throughout the study in patients using icodextrin, but decreased slightly in patients using only conventional dialysis solutions.

Conclusions: There were no major changes in dialysis adequacy or membrane characteristics during the follow-up period, but increased IL-6 in dialysate may reflect peritoneal inflammation, which may lead to long-term alterations in the peritoneal membrane. Icodextrin may have a preventive effect on the longevity of the peritoneal membrane.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / analysis
  • CA-125 Antigen / analysis*
  • Dialysis Solutions / chemistry*
  • Female
  • Follow-Up Studies
  • Humans
  • Hyaluronic Acid / analysis*
  • Intercellular Adhesion Molecule-1 / analysis*
  • Interleukin-6 / analysis*
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Peritoneum / physiology*
  • Peritonitis / etiology
  • Peritonitis / prevention & control
  • Prognosis
  • Renal Dialysis*
  • Retrospective Studies
  • Time Factors


  • Biomarkers
  • CA-125 Antigen
  • Dialysis Solutions
  • Interleukin-6
  • Intercellular Adhesion Molecule-1
  • Hyaluronic Acid