Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Neurosci Lett. 1992 Feb 3;135(2):235-8. doi: 10.1016/0304-3940(92)90444-c.


Many biochemically diverse proteins can give rise to amyloid fibrils; however, they are all accompanied by P component and glucosaminoglycans. With antibodies specific to apolipoprotein E (apo E) we used immunohistochemical techniques to test for the presence of this protein in both cerebral and systemic amyloid. We found apo E immunoreactivity in all tested types of cerebral and systemic amyloid. In amyloid deposits apo E P, component and glucosaminoglycans may be acting as 'pathological molecular chaperones'. The latter we define as a group of unrelated proteins that induce beta-pleated conformation in amyloidogenic polypeptides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amyloid / metabolism*
  • Apolipoproteins E / cerebrospinal fluid
  • Apolipoproteins E / immunology
  • Apolipoproteins E / metabolism*
  • Brain Chemistry / physiology*
  • Glycosaminoglycans / metabolism
  • Humans
  • Microscopy, Immunoelectron
  • Nervous System Diseases / metabolism*
  • Nervous System Diseases / pathology
  • Paraffin Embedding
  • Serum Amyloid P-Component / metabolism


  • Amyloid
  • Apolipoproteins E
  • Glycosaminoglycans
  • Serum Amyloid P-Component