A combined approach for locating box H/ACA snoRNAs in the human genome

Mol Cells. 2005 Aug 31;20(1):35-42.

Abstract

A novel combined method for locating box H/ACA small nucleolar RNAs (snoRNAs) is described, together with a software tool. The method adopts both a probabilistic hidden Markov model (HMM) and a minimum free energy (MFE) rule, and filters possible candidate box H/ACA snoRNAs obtained from genomic DNA sequences. With our novel method 12 known box H/ACA snoRNAs, and one strong candidate were identified in 30 nucleolar protein genomic sequences.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Base Sequence
  • Databases, Nucleic Acid
  • Energy Transfer / genetics*
  • Genome, Human*
  • Humans
  • Markov Chains*
  • Models, Biological
  • Molecular Sequence Data
  • RNA, Small Nucleolar / genetics*
  • Reproducibility of Results
  • Saccharomyces cerevisiae / genetics
  • Sequence Alignment
  • Software / standards*

Substances

  • RNA, Small Nucleolar