CDK-dependent stabilization of Cdc6: linking growth and stress signals to activation of DNA replication

Cell Cycle. 2005 Dec;4(12):1725-8. doi: 10.4161/cc.4.12.2193. Epub 2005 Dec 22.


Cyclin-dependent kinases (CDKs) play a crucial role in cell cycle progression by controlling the transition from G(1) phase into S phase where DNA is replicated. Key to this transition is the regulation of initiation of DNA replication at replication origins. CDKs are thought to regulate origins of replication both positively and negatively by phosphorylating replication proteins at origins. Several replication proteins that are potentially negatively regulated upon CDK phosphorylation have been identified. However, the mechanism by which CDKs activate replication is currently less well understood. New observations revealing that the initiation protein Cdc6 is stabilized by CDK2-dependent phosphorylation may give more insight in this process.

MeSH terms

  • Cell Cycle Proteins / metabolism*
  • Cyclin-Dependent Kinases / metabolism*
  • DNA Replication*
  • Models, Genetic
  • Origin Recognition Complex / genetics
  • Saccharomyces cerevisiae / growth & development*
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Signal Transduction*


  • CDC6 protein, S cerevisiae
  • Cell Cycle Proteins
  • Origin Recognition Complex
  • Saccharomyces cerevisiae Proteins
  • Cyclin-Dependent Kinases