Unselective use of intranasal mupirocin ointment for controlling propagation of methicillin-resistant Staphylococcus aureus in a thoracic surgery ward

J Infect Chemother. 2005 Oct;11(5):231-3. doi: 10.1007/s10156-005-0396-9.


We executed a blanket-use program of intranasal application of mupirocin ointment to control the propagation of methicillin-resistant Staphylococcus aureus (MRSA) that occurred in a thoracic surgery ward of a university hospital. During an intervention of 14 weeks, all patients admitted to the ward for scheduled surgery received the ointment to their nares three times daily for 3 days before surgery, once on return to the ward, and three times weekly for the following 2 weeks. None of 84 patients was newly colonized with MRSA, and the daily rates of patients with MRSA in a recovery room in the ward significantly decreased in the period. We consider that the unselective application of mupirocin ointment is one of the effective measures to control MRSA propagation in a thoracic surgery unit.

MeSH terms

  • Administration, Intranasal
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / administration & dosage*
  • Child
  • Child, Preschool
  • Female
  • Hospital Units*
  • Hospitals, University
  • Humans
  • Infant
  • Infant, Newborn
  • Infection Control / methods*
  • Japan
  • Male
  • Methicillin Resistance*
  • Middle Aged
  • Mupirocin / administration & dosage*
  • Nose / microbiology
  • Ointments / administration & dosage
  • Staphylococcal Infections / prevention & control
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification
  • Thoracic Surgery*
  • Tokyo


  • Anti-Bacterial Agents
  • Ointments
  • Mupirocin