Severe supravalvar aortic stenosis in familial homozygous hypercholesterolemia

Pediatr Cardiol. Mar-Apr 2006;27(2):282-5. doi: 10.1007/s00246-005-5809-0.

Abstract

Familial homozygous hypercholesterolemia is a rare disease with diverse clinical presentations. Patients often present with cutaneous xanthomas, particularly in the Achilles' tendon. They may have significant cardiovascular involvement, including premature atherosclerotic coronary artery disease and valvar and supravalvar aortic stenosis. Standard therapy includes diet modulation, pharmacotherapy, and lipid apheresis. Rarely, patients require surgical intervention for coronary artery bypass grafting and/or relief of the aortic stenosis. We present the case of a patient with severe progressive supravalvar aortic stenosis that ultimately required surgical resection despite aggressive medical therapy.

Publication types

  • Case Reports

MeSH terms

  • Aortic Stenosis, Supravalvular / etiology*
  • Aortic Stenosis, Supravalvular / pathology
  • Aortic Stenosis, Supravalvular / surgery
  • Atherosclerosis / etiology*
  • Atherosclerosis / pathology
  • Atherosclerosis / surgery
  • Child, Preschool
  • Disease Progression
  • Echocardiography
  • Humans
  • Hyperlipoproteinemia Type II / complications*
  • Hyperlipoproteinemia Type II / therapy
  • Male