Postprandial water intake inhibits gastric antral motility with increase of cholecystokinin in humans

Scand J Gastroenterol. 2005 Oct;40(10):1176-81. doi: 10.1080/00365520510023503.


Objective: The effects of postprandial water intake on the gastrointestinal tract have not been systematically investigated in humans.

Material and methods: In 8 healthy volunteers, the gastric antral pressure was measured with a strain gauge transducer, while the esophageal and lower esophageal sphincter pressures were measured with an infused catheter with a Dent sleeve. The esophageal pH at 5 cm above the lower sphincter was measured with a microglass electrode. A standard test meal (560 kcal) was eaten and 500 ml water was ingested 1 h later. The plasma cholecystokinin level was assessed at 4-min intervals. As a control, the same study was done on another day with sham water intake.

Results: At 4 min after water intake, there was a significant decrease in gastric antral motility and a significant increase in the plasma cholecystokinin level. Water intake also significantly increased the occurrence of gastroesophageal reflux.

Conclusions: The rapid increase in cholecystokinin after water intake may be initiated by a feedback mechanism related to inflow of fatty chyme into the duodenum that inhibits gastric antral activity.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biomarkers / blood
  • Cholecystokinin / blood*
  • Drinking / physiology*
  • Esophageal Sphincter, Lower / physiology
  • Fasting / physiology
  • Gastroesophageal Reflux / metabolism
  • Gastroesophageal Reflux / physiopathology
  • Gastrointestinal Motility / physiology*
  • Humans
  • Male
  • Manometry
  • Middle Aged
  • Postprandial Period / physiology*
  • Pyloric Antrum / metabolism
  • Pyloric Antrum / physiology*
  • Radioimmunoassay
  • Reference Values


  • Biomarkers
  • Cholecystokinin