Delayed profound respiratory depression after premedication with trimeprazine

Anaesthesia. 1992 Jul;47(7):585-6. doi: 10.1111/j.1365-2044.1992.tb02328.x.


Delayed, profound respiratory depression occurred in a 4-year-old boy, who had been premedicated with trimeprazine 4 h after tonsillectomy. This is a rare, but potentially fatal idiosyncratic reaction.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Humans
  • Male
  • Postoperative Complications / etiology*
  • Preanesthetic Medication / adverse effects*
  • Respiratory Insufficiency / chemically induced*
  • Tonsillectomy
  • Trimeprazine / adverse effects*


  • Trimeprazine