Animal models in oral cancer research

Oral Oncol. 2006 May;42(5):448-60. doi: 10.1016/j.oraloncology.2005.07.014. Epub 2005 Nov 2.


Biologically and clinically relevant animal models are essential in investigation of the progression of diseases and the elaboration of diagnostic or therapeutic protocols. The several rodent models used for in vivo evaluation for oral cancer employ chemical, transplantation and genetic (knockout and transgenic) induction methods. These models are described together with their advantages and disadvantages. Their optimization and application in future research may improve the early detection and treatment of oral cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / chemically induced
  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / genetics
  • Cocarcinogenesis
  • Disease Models, Animal*
  • Mice
  • Mice, Transgenic
  • Mouth Neoplasms / chemically induced
  • Mouth Neoplasms / etiology*
  • Mouth Neoplasms / genetics
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Neovascularization, Pathologic