A long-term double-blind clinical trial of ibuprofen and indomethacin in rheumatoid arthritis

J Int Med Res. 1975;3(3):158-71. doi: 10.1177/030006057500300304.

Abstract

Two-hundred and eighteen individuals with rheumatoid arthritis were randomly assigned to six months treatment with ibuprofen (900-1800 mg/day) or indomethacin (75-150 mg/day). The drugs were equally effective in the treatment of rheumatoid arthritis while the incidence of indomethacin side-effects was 1.5 times greater than the incidence of ibuprofen side-effects.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / physiopathology
  • Double-Blind Method
  • Female
  • Humans
  • Ibuprofen / adverse effects
  • Ibuprofen / therapeutic use*
  • Indomethacin / adverse effects
  • Indomethacin / therapeutic use*
  • Male
  • Middle Aged
  • Time Factors

Substances

  • Ibuprofen
  • Indomethacin