Long-term mortality outcome in patients with reactive amyloidosis associated with rheumatoid arthritis

Clin Rheumatol. 2006 Jul;25(4):498-505. doi: 10.1007/s10067-005-0079-z. Epub 2005 Nov 3.


It is well established that amyloidosis is a serious clinical complication that can influence the prognosis of patients with rheumatoid arthritis (RA). The purpose of the study was to obtain information on the survival and the hemodialysis (HD) of patients with amyloidosis. Eighty patients (9 men and 71 women) who were diagnosed with amyloidosis by biopsy and definite or classical RA were studied retrospectively. The average duration of RA prior to the diagnosis of amyloidosis was 15.4+/-9.4 years. The average period from the diagnosis of amyloidosis to death was 67.4 months. Forty-nine patients died of the disease (32 cases with HD and 17 cases without HD). Thirty-one patients lived (7 cases with HD and 24 cases without HD). Regarding the survival of these patients, 49 (61.3%) of the 80 patients have died. Survival rate at 28 months was 75%; at 67 months, it was 50%; and at 111 months, it was down to 25%. Mortality rate was 11.9% per year. Survival rate in dialysis at 9.8 months was 75%; at 60.6 months, it dropped to 50%; and at 100.0 months, to 25%. As for patients' survival, high onset age of amyloidosis was the major determining factor for poor survival in these patients (p<0.001). Furthermore, male patients also had poor survival (p=0.07). The long-term results were very encouraging to initiate HD in patients with end-stage renal disease due to reactive amyloidosis associated with RA.

MeSH terms

  • Age of Onset
  • Amyloid / analysis
  • Amyloidosis / diagnosis
  • Amyloidosis / mortality*
  • Amyloidosis / therapy
  • Arthritis, Rheumatoid / mortality*
  • Arthritis, Rheumatoid / physiopathology
  • Biopsy
  • Cause of Death
  • Comorbidity
  • Female
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Renal Dialysis / statistics & numerical data
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis


  • Amyloid