Imaging in cell-based therapy for neurodegenerative diseases

Eur J Nucl Med Mol Imaging. 2005 Dec;32 Suppl 2:S417-34. doi: 10.1007/s00259-005-1909-6.

Abstract

Fetal cell transplantation for the treatment of Parkinson's and Huntington's diseases has been developed over the past two decades and is now in early clinical testing phase. Direct assessment of the graft's survival, integration into the host brain and impact on neuronal functions requires advanced in vivo neuroimaging techniques. Owing to its high sensitivity, positron emission tomography is today the most widely used tool to evaluate the viability and function of the transplanted tissue in the brain. Nuclear magnetic resonance techniques are opening new possibilities for imaging neurochemical events in the brain. The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diagnostic Imaging / methods*
  • Diagnostic Imaging / trends
  • Gene Expression Profiling / methods*
  • Gene Expression Profiling / trends
  • Humans
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Imaging / trends
  • Molecular Probe Techniques
  • Nerve Regeneration
  • Neurodegenerative Diseases / diagnosis*
  • Neurodegenerative Diseases / surgery*
  • Positron-Emission Tomography / methods
  • Positron-Emission Tomography / trends
  • Stem Cell Transplantation / methods*
  • Stem Cells / diagnostic imaging*
  • Stem Cells / pathology*