A six-step asymmetric synthesis of (+)-hyperaspine

Daniel L Comins; James J Sahn

doi:10.1021/ol052068v

A six-step asymmetric synthesis of (+)-hyperaspine

Org Lett. 2005 Nov 10;7(23):5227-8. doi: 10.1021/ol052068v.

Authors

Daniel L Comins¹, James J Sahn

Affiliation

¹ Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA. daniel_comins@ncsu.edu

PMID: 16268544
DOI: 10.1021/ol052068v

Abstract

[reaction: see text] The ladybird alkaloid, (+)-hyperaspine, has been synthesized in a concise and highly stereoselective manner. The total synthesis was accomplished in six steps and 21% overall yield.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alkaloids / chemical synthesis*
Alkaloids / chemistry
Catalysis
Molecular Structure
Piperidines / chemistry
Quinolizines / chemical synthesis*
Quinolizines / chemistry
Stereoisomerism

Substances

Alkaloids
Piperidines
Quinolizines
hyperaspine