Serotonin and depression: a disconnect between the advertisements and the scientific literature

PLoS Med. 2005 Dec;2(12):e392. doi: 10.1371/journal.pmed.0020392. Epub 2005 Nov 8.

Abstract

Many ads for SSRI antidepressants claim that the drugs boost brain serotonin levels. Lacasse and Leo argue there is little scientific evidence to support this claim.

Publication types

  • Review

MeSH terms

  • Advertising*
  • Antidepressive Agents / therapeutic use*
  • Community Participation
  • Depression / drug therapy*
  • Depression / physiopathology*
  • Humans
  • Randomized Controlled Trials as Topic
  • Serotonin / metabolism
  • Serotonin / physiology*
  • Serotonin Uptake Inhibitors / therapeutic use*
  • United States
  • United States Food and Drug Administration

Substances

  • Antidepressive Agents
  • Serotonin Uptake Inhibitors
  • Serotonin