Serum Osteoprotegerin Levels Are Associated With Inflammation and Pulse Wave Velocity

Clin Endocrinol (Oxf). 2005 Nov;63(5):594-8. doi: 10.1111/j.1365-2265.2005.02390.x.

Abstract

Objective: We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients.

Patients and measurements: The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured.

Results: Serum OPG levels (6.1 +/- 1.4 vs. 5.4 +/- 1.3 pmol/l, P = 0.011) and baPWV (1562 +/- 354 vs. 1399 +/- 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R(2) = 0.299).

Conclusions: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

MeSH terms

  • Biomarkers / blood
  • Blood Glucose / analysis
  • Brachial Artery / physiopathology
  • C-Reactive Protein / analysis
  • Case-Control Studies
  • Diabetes Mellitus / blood*
  • Diabetes Mellitus / physiopathology
  • Female
  • Glycoproteins / blood*
  • Humans
  • Hypertension / blood*
  • Hypertension / physiopathology
  • Inflammation / blood
  • Inflammation / physiopathology
  • Insulin Resistance
  • Interleukin-6 / blood
  • Lipids / blood
  • Male
  • Middle Aged
  • Osteoprotegerin
  • Pulsatile Flow
  • Receptors, Cytoplasmic and Nuclear / blood*
  • Receptors, Tumor Necrosis Factor / blood*
  • Regression Analysis
  • Signal Processing, Computer-Assisted
  • Systole
  • Triglycerides / blood

Substances

  • Biomarkers
  • Blood Glucose
  • Glycoproteins
  • Interleukin-6
  • Lipids
  • Osteoprotegerin
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Tumor Necrosis Factor
  • TNFRSF11B protein, human
  • Triglycerides
  • C-Reactive Protein