The role of hybrid PET/CT in the evaluation of patients with cervical cancer

Gynecol Oncol. 2006 Jan;100(1):65-9. doi: 10.1016/j.ygyno.2005.07.013. Epub 2005 Nov 2.


Objective: To assess the role of hybrid PET/CT in the evaluation of patients with cervical cancer.

Methods: 75 patients divided into 3 groups. Group 1 consisted of 16 patients prior to radical surgery. Group 2 consisted of 31 patients prior to pelvic radiotherapy. Group 3 had 28 patients who underwent the examination secondary to suspected recurrent disease. Whole body PET and CT were performed respectively on the same device 1 h after injection of 10 mCi FDG. PET/CT results were correlated to histological, radiological and clinical follow-up data. Only women with >6 months follow-up were included.

Results: In 33 patients, pathohistological examinations for extra cervical lesions were obtained. Correlation with PET/CT examination revealed levels of sensitivity (60%), specificity (94%), positive (90%) and negative predictive values (74%). The examination indicated 21 patients with extrapelvic and/or metastatic disease. The follow-up data of this group revealed that 20 patients either died or were alive with active disease, and only one patient was in clinical remission. PET/CT yielded an improved diagnosis for both PET and CT in 43% of the cases by providing better localization and definition of abnormal FDG uptake.

Conclusions: Hybrid PET/CT was found to be of value for detection of cervical cancer metastases, decision-making and planning of irradiation therapy. Using this modality may reduce unnecessary surgical interventions, help modify radiation fields and change therapeutic approaches. Detection of advanced diseases on PET/CT correlates with poor prognosis. However, this examination is less accurate in detecting microscopic diseases and lesions smaller than 1.5 cm.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Fluorodeoxyglucose F18 / pharmacokinetics
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Neoplasm Recurrence, Local / metabolism
  • Neoplasm Recurrence, Local / pathology*
  • Positron-Emission Tomography
  • Radiopharmaceuticals / pharmacokinetics
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed
  • Ultrasonography
  • Uterine Cervical Neoplasms / diagnostic imaging*
  • Uterine Cervical Neoplasms / metabolism
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / surgery
  • Whole Body Imaging


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18