The proteasome: not just degrading anymore

Cell. 2005 Nov 4;123(3):361-3. doi: 10.1016/j.cell.2005.10.013.


The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.

Publication types

  • Comment

MeSH terms

  • Gene Expression Regulation, Fungal
  • Histones / metabolism
  • Promoter Regions, Genetic*
  • Proteasome Endopeptidase Complex / genetics
  • Proteasome Endopeptidase Complex / physiology*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / physiology*
  • Transcriptional Activation
  • Ubiquitins / metabolism


  • Histones
  • NAS6 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Ubiquitins
  • Proteasome Endopeptidase Complex