The proteasome: not just degrading anymore

Stephen P Baker; Patrick A Grant

doi:10.1016/j.cell.2005.10.013

The proteasome: not just degrading anymore

Cell. 2005 Nov 4;123(3):361-3. doi: 10.1016/j.cell.2005.10.013.

Authors

Stephen P Baker¹, Patrick A Grant

Affiliation

¹ Department of Biochemistry and Molecular Genetics, University of Virginia Schol of Medicine, Charlottesville, Virginia 22908, USA.

PMID: 16269325
DOI: 10.1016/j.cell.2005.10.013

Abstract

The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.

Publication types

Comment

MeSH terms

Gene Expression Regulation, Fungal
Histones / metabolism
Promoter Regions, Genetic*
Proteasome Endopeptidase Complex / genetics
Proteasome Endopeptidase Complex / physiology*
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae / physiology*
Saccharomyces cerevisiae Proteins / genetics
Saccharomyces cerevisiae Proteins / physiology*
Transcriptional Activation
Ubiquitins / metabolism

Substances

Histones
NAS6 protein, S cerevisiae
Saccharomyces cerevisiae Proteins
Ubiquitins
Proteasome Endopeptidase Complex