Abstract
The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.
MeSH terms
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Gene Expression Regulation, Fungal
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Histones / metabolism
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Promoter Regions, Genetic*
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Proteasome Endopeptidase Complex / genetics
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Proteasome Endopeptidase Complex / physiology*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / physiology*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / physiology*
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Transcriptional Activation
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Ubiquitins / metabolism
Substances
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Histones
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NAS6 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Ubiquitins
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Proteasome Endopeptidase Complex