Humans as an animal model for systems-level organization of olfaction

Neuron. 2005 Nov 3;48(3):431-54. doi: 10.1016/j.neuron.2005.10.009.


The past 15 years have seen significant advances in the study of olfaction, with particular emphasis on elucidating the molecular building blocks of the sensory process. However, much of the systems-level organization of olfaction remains unexplored. Here, we provide an overview at this level, highlighting results obtained from studying humans, whom we think provide an underutilized, yet critical, animal model for olfaction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / anatomy & histology
  • Brain / physiology
  • Humans
  • Models, Animal*
  • Models, Biological
  • Olfactory Pathways / cytology
  • Olfactory Pathways / physiology*
  • Olfactory Receptor Neurons / physiology*
  • Receptors, Odorant / physiology
  • Smell / physiology*


  • Receptors, Odorant