A model of anxious depression: persistence of behavioral pathology

Neurosci Behav Physiol. 2005 Nov;35(9):917-24. doi: 10.1007/s11055-005-0146-6.


Chronic psychoemotional stress induced by negative experience of social defeats in intermale confrontations over a period of 30 days was found to lead to the development of anxious-depressive symptomatology in male mice. Cessation of the psychopathogenic conditions and placing of depressed animals in comfortable conditions for 1-2 weeks with females did not lift the pathological state. Individuals continued to show marked anxiety, a behavioral deficit, decreased communicativeness, and a high level of depressivity, as revealed by a variety of behavioral tests. Persistence of the resulting psychoemotional disturbance in these animals is evidence for the development and persistence of the behavioral pathology requiring drug treatment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animal Communication
  • Animals
  • Anxiety Disorders / physiopathology*
  • Anxiety Disorders / psychology*
  • Behavior, Animal*
  • Conflict, Psychological
  • Depression / physiopathology*
  • Depression / psychology*
  • Disease Models, Animal
  • Exploratory Behavior / physiology
  • Female
  • Male
  • Maze Learning / physiology
  • Mice
  • Mice, Inbred C57BL
  • Movement / physiology
  • Reaction Time / physiology
  • Statistics, Nonparametric