Inherited ACTH insensitivity illuminates the mechanisms of ACTH action

Trends Endocrinol Metab. 2005 Dec;16(10):451-7. doi: 10.1016/j.tem.2005.10.006. Epub 2005 Nov 3.


Adrenocorticotrophin (ACTH) insensitivity is a potentially lethal inherited disorder of ACTH signalling in the adrenal. Inactivating mutations of the ACTH receptor account for approximately 25% of these cases. A second genetic cause for this syndrome has recently been identified in the MRAP gene. The MRAP protein appears to function in the trafficking and cell surface expression of the ACTH receptor, and might indicate the existence of more widespread G-protein-coupled receptor trafficking mechanisms. Molecular defects underlying other causes of ACTH insensitivity syndromes will probably contribute further to our understanding of these pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenocorticotropic Hormone / pharmacology
  • Adrenocorticotropic Hormone / physiology*
  • Animals
  • Body Height
  • Codon, Nonsense
  • Drug Resistance / genetics*
  • Glucocorticoids / deficiency
  • Humans
  • Intracellular Signaling Peptides and Proteins / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Membrane Transport Proteins / genetics
  • Mutation, Missense
  • Promoter Regions, Genetic / genetics
  • Receptor Activity-Modifying Proteins
  • Receptor, Melanocortin, Type 2 / genetics*
  • Receptors, Corticotropin / genetics
  • Receptors, G-Protein-Coupled / physiology


  • Codon, Nonsense
  • Glucocorticoids
  • Intracellular Signaling Peptides and Proteins
  • MRAP protein, human
  • Membrane Proteins
  • Membrane Transport Proteins
  • RTP1 protein, human
  • Receptor Activity-Modifying Proteins
  • Receptor, Melanocortin, Type 2
  • Receptors, Corticotropin
  • Receptors, G-Protein-Coupled
  • Adrenocorticotropic Hormone