Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

Nat Med. 2005 Dec;11(12):1293-4. doi: 10.1038/nm1321. Epub 2005 Nov 6.

Abstract

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Animals
  • CCR5 Receptor Antagonists*
  • Female
  • Macaca / virology*
  • Pyrazoles / administration & dosage
  • Pyrazoles / pharmacology*
  • Simian Acquired Immunodeficiency Syndrome / prevention & control*
  • Simian Immunodeficiency Virus / drug effects*
  • Time Factors
  • Vagina / drug effects
  • Vagina / virology*
  • Valine / administration & dosage
  • Valine / analogs & derivatives*
  • Valine / pharmacology
  • Viral Load

Substances

  • CCR5 Receptor Antagonists
  • N-(3-(3-fluorophenyl)-4-((4-(3-benzyl-1-ethylpyrazol-5-yl)piperidin-1-yl)methyl)cyclopentyl)-N-methylvaline
  • Pyrazoles
  • Valine