Chronic hepatitis C virus infection and post-liver transplantation diabetes mellitus

World J Gastroenterol. 2005 Oct 21;11(39):6085-9. doi: 10.3748/wjg.v11.i39.6085.

Abstract

Patients with chronic hepatitis C virus (HCV) infection have a significantly increased prevalence of type 2 diabetes mellitus compared to controls or HBV-infected patients. Moreover, the incidence rate of post-liver transplantation diabetes mellitus (PTDM) also appears to be higher among patients with HCV infection. PTDM is often associated with direct viral infection, autoimmune disorders, and immunosuppressive regimen. Activation of tumor necrosis factor-alpha may be the link between HCV infection and diabetes. In this article, we reviewed the epidemiologic association between HCV infection and PTDM, highlighting the most recent pathophysiologic insights into the mechanisms underlying this association.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / immunology
  • Hepatitis C, Chronic / epidemiology*
  • Hepatitis C, Chronic / surgery*
  • Humans
  • Immunosuppression Therapy / adverse effects
  • Liver Transplantation*
  • Postoperative Complications / epidemiology
  • Postoperative Complications / immunology