Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

Trends Endocrinol Metab. 2005 Dec;16(10):478-88. doi: 10.1016/j.tem.2005.10.005. Epub 2005 Nov 4.


Small heterodimer partner (SHP; NR0B2), an exceptional member of the mammalian nuclear receptor family, directly modulates the activities of conventional nuclear receptors by acting as an inducible and tissue-specific corepressor. Recent progress in dissecting underlying molecular mechanisms, identifying target factors and target genes, and uncovering physiological functions points to the regulatory involvement of SHP in diverse metabolic and intracellular pathways that awaits future clarification. In this review, we carry out a comprehensive survey of all published data and discuss our current understanding of molecular mechanisms and physiological consequences governing SHP action.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bile Acids and Salts / biosynthesis
  • Binding Sites
  • Feedback, Physiological
  • Gene Expression Regulation / physiology*
  • Humans
  • Ligands
  • Liver / metabolism
  • Protein Interaction Mapping
  • Protein Structure, Tertiary
  • Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Repressor Proteins / physiology*
  • Transcription Factors / physiology


  • Bile Acids and Salts
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Repressor Proteins
  • Transcription Factors
  • nuclear receptor subfamily 0, group B, member 2