Dysmenorrhea is a significant problem in adolescents. Routine medical management has included analgesics and prostaglandin inhibitors. We describe the use of a calcium channel blocker, nicardipine, in the management of an adolescent who was refractory in routine treatment for severe dysmenorrhea. The patient had excellent resolution of menstrual cramping without serious side effects. The role of calcium channel blockers in the management of refractory dysmenorrhea should be further studied to examine a future role.