Eye movement abnormalities in stiff person syndrome

Neurology. 2005 Nov 8;65(9):1462-4. doi: 10.1212/01.wnl.0000183068.42803.33.

Abstract

The authors describe a 38-year-old woman with stiff person syndrome (SPS) and gaze-holding nystagmus, limited abduction, vertical and horizontal ocular misalignment, deficient smooth pursuit, and impaired saccade initiation. There was no evidence of ocular myasthenia, indicating that abnormalities of ocular motor function can occur as a primary manifestation of SPS, perhaps from depletion of GABA.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Atrophy / diagnosis
  • Atrophy / etiology
  • Atrophy / physiopathology
  • Brain Stem / metabolism
  • Brain Stem / physiopathology
  • Cerebellar Diseases / diagnosis
  • Cerebellar Diseases / etiology
  • Cerebellar Diseases / physiopathology
  • Cerebellum / pathology
  • Cerebellum / physiopathology
  • Female
  • Glutamate Decarboxylase / deficiency
  • Glutamate Decarboxylase / immunology
  • Humans
  • Magnetic Resonance Imaging
  • Muscle Spasticity / diagnosis
  • Muscle Spasticity / etiology
  • Muscle Spasticity / physiopathology
  • Neural Inhibition / immunology
  • Neural Pathways / metabolism
  • Neural Pathways / physiopathology
  • Neurologic Examination
  • Nystagmus, Pathologic / diagnosis
  • Nystagmus, Pathologic / etiology
  • Nystagmus, Pathologic / physiopathology
  • Ocular Motility Disorders / diagnosis
  • Ocular Motility Disorders / etiology*
  • Ocular Motility Disorders / physiopathology*
  • Oculomotor Muscles / innervation
  • Oculomotor Muscles / physiopathology*
  • Stiff-Person Syndrome / complications*
  • Stiff-Person Syndrome / diagnosis
  • Stiff-Person Syndrome / physiopathology*
  • gamma-Aminobutyric Acid / metabolism

Substances

  • gamma-Aminobutyric Acid
  • Glutamate Decarboxylase