Age-related Changes in Cerebrospinal Fluid Gamma-Aminobutyric Acid Concentration

Eur J Clin Chem Clin Biochem. 1992 May;30(5):271-4. doi: 10.1515/cclm.1992.30.5.271.


The purpose of this study was to clarify the effect of aging on brain gamma-aminobutyric acid metabolism. We measured the cerebrospinal fluid gamma-aminobutyric acid concentration in subjects of various ages, including healthy volunteers and patients without neurological or psychiatric disease. The cerebrospinal fluid gamma-aminobutyric acid concentration was determined by radiolabelled receptor assay using [3H]gamma-aminobutyric acid. Cerebrospinal fluid gamma-aminobutyric acid was significantly higher in the control group (20s and 30s) than in the groups of subjects in their 50s, 60s, 70s and 80s. There was a significant negative correlation between cerebrospinal gamma-aminobutyric acid concentration and age (p less than 0.01). These data suggest that dysfunction of brain gamma-aminobutyric acid metabolism increases with age, and that the various symptoms caused by abnormal gamma-aminobutyric acid metabolism in the brain are therefore more likely to appear in elderly people.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Animals
  • Brain / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Radioligand Assay
  • Rats
  • Rats, Inbred Strains
  • Tritium
  • gamma-Aminobutyric Acid / cerebrospinal fluid*
  • gamma-Aminobutyric Acid / metabolism


  • Tritium
  • gamma-Aminobutyric Acid