Clinical review: role of triggering receptor expressed on myeloid cells-1 during sepsis

Crit Care. 2005 Oct 5;9(5):485-9. doi: 10.1186/cc3732. Epub 2005 Jun 3.


Triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule that is involved in monocytic activation and in the inflammatory response. It belongs to a family related to the natural killer cell receptors and is expressed on neutrophils, mature monocytes and macrophages. The inflammatory response mediated by Toll-like receptor-2 and -4 stimulation is amplified by the engagement of TREM-1. The expression of membrane-bound TREM-1 is greatly increased on monocytes during sepsis. Moreover, infection induces the release of a soluble form of this receptor, which can be measured in biological fluid and may be useful as a diagnostic tool. Modulation of the TREM-1 signalling pathway by the use of small synthetic peptides confers interesting survival advantages during experimental septic shock in mice, even when this teatment is administered late after the onset of sepsis.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Humans
  • Immunoglobulin G / therapeutic use
  • Inflammation Mediators / antagonists & inhibitors
  • Inflammation Mediators / metabolism*
  • Membrane Glycoproteins / antagonists & inhibitors
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Receptors, Immunologic / antagonists & inhibitors
  • Receptors, Immunologic / metabolism*
  • Sepsis / diagnosis*
  • Sepsis / metabolism
  • Sepsis / therapy
  • Triggering Receptor Expressed on Myeloid Cells-1


  • Biomarkers
  • Immunoglobulin G
  • Inflammation Mediators
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • Treml1 protein, mouse
  • Triggering Receptor Expressed on Myeloid Cells-1