Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial

J Clin Endocrinol Metab. 2006 Feb;91(2):405-12. doi: 10.1210/jc.2005-1436. Epub 2005 Nov 8.


Background: Despite the high prevalence of hypovitaminosis D in children and adolescents worldwide, the impact of vitamin D deficiency on skeletal health is unclear.

Methods: One hundred seventy-nine girls, ages 10-17 yr, were randomly assigned to receive weekly oral vitamin D doses of 1,400 IU (equivalent to 200 IU/d) or 14,000 IU (equivalent to 2,000 IU/d) in a double-blind, placebo-controlled, 1-yr protocol. Areal bone mineral density (BMD) and bone mineral content (BMC) at the lumbar spine, hip, forearm, total body, and body composition were measured at baseline and 1 yr. Serum calcium, phosphorus, alkaline phosphatase, and vitamin D metabolites were measured during the study.

Results: In the overall group of girls, lean mass increased significantly in both treatment groups (P < or = 0.05); bone area and total hip BMC increased in the high-dose group (P < 0.02). In premenarcheal girls, lean mass increased significantly in both treatment groups, and there were consistent trends for increments in BMD and/or BMC at several skeletal sites, reaching significance at lumbar spine BMD in the low-dose group and at the trochanter BMC in both treatment groups. There was no significant change in lean mass, BMD, or BMC in postmenarcheal girls.

Conclusions: Vitamin D replacement had a positive impact on musculoskeletal parameters in girls, especially during the premenarcheal period.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alkaline Phosphatase / blood
  • Body Composition / drug effects
  • Body Composition / physiology
  • Bone Density / drug effects*
  • Calcium / blood
  • Child
  • Double-Blind Method
  • Exercise / physiology
  • Female
  • Hand Strength / physiology
  • Humans
  • Lebanon
  • Multivariate Analysis
  • Musculoskeletal Development / drug effects*
  • Musculoskeletal Development / physiology
  • Phosphorus / blood
  • Regression Analysis
  • Solar System
  • Vitamin D / administration & dosage*


  • Vitamin D
  • Phosphorus
  • Alkaline Phosphatase
  • Calcium