Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: a randomized, controlled trial

Acta Paediatr. 2005 Sep;94(9):1208-13. doi: 10.1111/j.1651-2227.2005.tb02076.x.


Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis.

Methods: Eighty-two children (4-10 y) with acute respiratory symptoms and ultrasonography findings suggestive of acute rhinosinusitis were enrolled in a randomized, double-blind trial. The sinus findings were confirmed with plain radiographs. The children received either cefuroxime axetil in 125-mg capsules twice a day for 10 d or placebo. Main outcome measures were complete cure in 2 wk and absence of prolonged symptoms or complications.

Results: A total of 72 children (88%) completed follow-up. The sinusitis findings in the ultrasound could be confirmed with plain radiographs in 65 of the 72 patients (90%). The proportion of children completely cured by day 14 was similar in both groups (difference 6%, 95% confidence interval -16% to 29%). Similarly, there was no significant difference in the proportions of children who escaped prolonged disease and complications between the groups (difference 7%, -9% to 24%).

Conclusion: A 10-d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Anti-Bacterial Agents / therapeutic use
  • Cefuroxime / analogs & derivatives*
  • Cefuroxime / therapeutic use
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Placebos
  • Respiratory Tract Infections / complications
  • Respiratory Tract Infections / drug therapy*
  • Sinusitis / complications
  • Sinusitis / drug therapy*
  • Time Factors
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Placebos
  • Cefuroxime
  • cefuroxime axetil