Abstract
To determine the origin of benign cystic teratomas of the ovary, chromosome-banding studies were done on normal tissues and teratomas from five patients. The normal tissues were heterozygous (+/-) for 17 chromosome polymorphisms at or near the centromere, whereas the teratomas were uniformly homozygous (+/+ or -/-). These findings and those employing electrophoretic variants indicate that ovarian teratomas are parthenogenic tumors that arise from a single germ cell after the first meiotic division.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Aminohydrolases / metabolism
-
Cells, Cultured
-
Chromosomes
-
Dermoid Cyst / enzymology
-
Dermoid Cyst / genetics
-
Dermoid Cyst / pathology*
-
Electrophoresis
-
Female
-
Germ Cells
-
Heterozygote
-
Homozygote
-
Humans
-
Karyotyping
-
L-Lactate Dehydrogenase / metabolism
-
Meiosis
-
Ovarian Neoplasms / enzymology
-
Ovarian Neoplasms / genetics
-
Ovarian Neoplasms / pathology*
-
Parthenogenesis
-
Pentosyltransferases / metabolism
-
Phosphoglucomutase / metabolism
-
Phosphogluconate Dehydrogenase / metabolism
-
Phosphotransferases / metabolism
-
Polymorphism, Genetic
Substances
-
L-Lactate Dehydrogenase
-
Phosphogluconate Dehydrogenase
-
Pentosyltransferases
-
Phosphotransferases
-
Aminohydrolases
-
Phosphoglucomutase