Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation

Br J Haematol. 2005 Nov;131(4):483-6. doi: 10.1111/j.1365-2141.2005.05797.x.


Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0.01) and disease-free survival (P = 0.02), resulting from increased relapse rate (P = 0.02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Genotype
  • HLA-C Antigens / genetics*
  • Hematologic Neoplasms / genetics
  • Hematologic Neoplasms / therapy*
  • Hematopoietic Stem Cell Transplantation*
  • Histocompatibility
  • Histocompatibility Testing
  • Homozygote
  • Humans
  • Infant
  • Ligands
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Receptors, Immunologic / genetics*
  • Receptors, KIR2DL1
  • Recurrence
  • Survival Analysis


  • HLA-C Antigens
  • KIR2DL1 protein, human
  • Ligands
  • Receptors, Immunologic
  • Receptors, KIR2DL1