Potassium channels, memory T cells, and multiple sclerosis

Neuroscientist. 2005 Dec;11(6):550-62. doi: 10.1177/1073858405278016.


Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal damage that result in disabling neurological deficits. Here the authors explain the rationale for the use of inhibitors of the Kv1.3 K+ channel in immune cells as a therapy for multiple sclerosis and other autoimmune disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / drug therapy
  • Autoimmunity
  • Humans
  • Immunologic Memory*
  • Kv1.3 Potassium Channel / antagonists & inhibitors*
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / metabolism
  • Multiple Sclerosis / physiopathology*
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*


  • Kv1.3 Potassium Channel