Intracranial plasma cell granuloma: case report and treatment of recurrence with methotrexate and 6-mercaptopurine

J Pediatr Hematol Oncol. 2005 Nov;27(11):599-603. doi: 10.1097/01.mph.0000184636.94923.58.


Plasma cell granulomas are a rare form of idiopathic inflammatory pseudotumors often characterized by non-neoplastic proliferation of plasma cells, clinically mimicking a neoplastic process. Pseudotumors of the central nervous system, however, are exceptional and rare. The authors describe a 14-year-old girl with a mass lesion extending medially along the cavernous sinus into the right middle cranial fossa and pterygopalatine and infratemporal fossae. The authors review the current literature and discuss successful treatment with methotrexate and 6-mercaptopurine after recurrence of disease following radiation therapy and steroids.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Brain Diseases / drug therapy*
  • Brain Diseases / pathology
  • Drug Therapy, Combination
  • Female
  • Granuloma, Plasma Cell / drug therapy*
  • Granuloma, Plasma Cell / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Mercaptopurine / therapeutic use*
  • Methotrexate / therapeutic use*
  • Recurrence


  • Mercaptopurine
  • Methotrexate