Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromsø study

J Neurol. 2006 Apr;253(4):464-70. doi: 10.1007/s00415-005-0027-5. Epub 2005 Nov 14.

Abstract

There are receptors for parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D in the brain, and there are clinical and experimental data indicating that PTH and vitamin D may affect cerebral function. In the present study 21 subjects who both in the 5th Tromsø study and at a follow-up examination fulfilled criteria for secondary hyperparathyroidism (SHPT) without renal failure (serum calcium < 2.40 mmol/L, serum PTH > 6.4 pmol/L, and normal serum creatinine) and 63 control subjects were compared with tests for cognitive and emotional function. Those in the SHPT group had significantly impaired performance in 3 of 14 cognitive tests (Digit span forward, Stroop test part 1 and 2, and Word association test (FAS)) as compared with the controls, and also had a significantly higher depression score at the Beck Depression Inventory (BDI) (items 1-13). In a multiple linear regression model, a high serum PTH level was significantly associated with low performance at the Digit span forward, Stroop test part 1 and 2, and Digit Symbol tests. A low level of serum 25-hydroxyvitamin D was significantly associated with a high depression score. In conclusion, a deranged calcium metabolism appears to be associated with impaired function in several tests of neuropsychological function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Affect / physiology
  • Aged
  • Calcitriol / blood*
  • Calcium / blood
  • Cognition / physiology
  • Depression / etiology
  • Depression / psychology
  • Female
  • Humans
  • Hyperparathyroidism, Secondary / blood*
  • Hyperparathyroidism, Secondary / psychology*
  • Male
  • Memory / physiology
  • Memory, Short-Term / physiology
  • Mental Health
  • Middle Aged
  • Neuropsychological Tests*
  • Norway / epidemiology
  • Parathyroid Hormone / blood*
  • Verbal Behavior
  • Wechsler Scales
  • Word Association Tests

Substances

  • Parathyroid Hormone
  • Calcitriol
  • Calcium