Sirolimus-induced acneiform eruption

N Kunzle; J-P Venetz; M Pascual; R G Panizzon; E Laffitte

doi:10.1159/000088511

Sirolimus-induced acneiform eruption

Dermatology. 2005;211(4):366-9. doi: 10.1159/000088511.

Authors

N Kunzle¹, J-P Venetz, M Pascual, R G Panizzon, E Laffitte

Affiliation

¹ Department of Dermatology and Venerology, DHURDV, Lausanne, Switzerland.

PMID: 16286750
DOI: 10.1159/000088511

Abstract

Sirolimus is a new immunosuppressive agent used to prevent rejection in renal allograft recipients in order to reduce the need of potentially nephrotoxic calcineurin inhibitors (cyclosporine, tacrolimus). The cutaneous side effects of sirolimus are not well known and they may have been underestimated. We report 2 cases of follicular acneiform eruptions induced by sirolimus in renal allograft recipients. This dermatologic complication was severe and difficult to treat, and resolved only after discontinuation of sirolimus.

Publication types

Case Reports

MeSH terms

Acneiform Eruptions / chemically induced*
Adult
Drug Eruptions / etiology*
Facial Dermatoses / chemically induced*
Female
Graft Survival
Humans
Immunosuppressive Agents / adverse effects*
Kidney Transplantation
Sirolimus / adverse effects*
Transplantation, Homologous

Substances

Immunosuppressive Agents
Sirolimus