Akt-dependent transformation: there is more to growth than just surviving

Oncogene. 2005 Nov 14;24(50):7435-42. doi: 10.1038/sj.onc.1209097.


Activation of the Akt/PKB protein kinase family triggers increases in cell size, metabolism and survival. Akt coordinately regulates these fundamental cellular processes through phosphorylation-dependent inactivation of tumor suppressors and activation of trophic signaling. Akt signaling stimulates transport and metabolism of both glucose and amino acids, which in turn support mTOR-dependent increases in protein translation. In addition, Akt activation directs cells to undertake a metabolic conversion from oxidative phosphorylation to aerobic glycolysis. Although this conversion promotes cell growth, it also renders cell survival dependent on a continuous supply of extracellular nutrients, which themselves are required regulatory elements in Akt signal transduction.

Publication types

  • Review

MeSH terms

  • Cell Enlargement
  • Cell Survival
  • Cell Transformation, Neoplastic*
  • Forkhead Transcription Factors / physiology
  • Glycolysis
  • Phosphorylation
  • Proto-Oncogene Proteins c-akt / physiology*
  • Signal Transduction


  • Forkhead Transcription Factors
  • Proto-Oncogene Proteins c-akt