Signaling roles of diacylglycerol kinases

J Cell Biochem. 2006 Feb 15;97(3):474-84. doi: 10.1002/jcb.20704.


Diacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution. Their kinase activity is regulated by mechanisms that modify their access to diacylglycerol, directly affect their kinase activity, or alter their ability to bind to other proteins. In many cases, these enzymes regulate the activity of proteins that are modulated by either diacylglycerol or PA. Experiments using cultured cells and model organisms have demonstrated that DGKs have prominent roles in neuronal transmission, lymphocyte signaling, and carcinogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diacylglycerol Kinase / metabolism*
  • Diglycerides / metabolism
  • Humans
  • Inositol Phosphates / metabolism
  • Models, Biological
  • Phosphatidic Acids / metabolism
  • Signal Transduction*


  • Diglycerides
  • Inositol Phosphates
  • Phosphatidic Acids
  • Diacylglycerol Kinase