PTEN expression in clear cell adenocarcinoma of the ovary

Gynecol Oncol. 2006 Apr;101(1):71-5. doi: 10.1016/j.ygyno.2005.09.047. Epub 2005 Nov 10.


Objectives: In this study, we analyzed the PTEN expression in a large collection of clear cell adenocarcinomas of the ovary. Furthermore, we analyzed the expression of cyclin D1 and p27, and investigated the correlation among all these variables.

Methods: Totally, 40 clear cell adenocarcinomas were included in this study. The protein expression of PTEN, cyclin D1 and p27 was investigated by immunohistochemistry.

Results: Of 40 clear cell adenocarcinomas, 15 (37.5%) lost all PTEN immunoreactivity. There was no significant correlation between PTEN expression and clinical stage. Cyclin D1 expression and loss of p27 expression were detected in 16/40 (40.0%) and 14/40 (35.0%) clear cell adenocarcinoma cases. There was no significant correlation between PTEN expression and cyclin D1 or p27 protein expression.

Conclusions: Loss of PTEN expression is relatively common and both cyclin D1 and p27 expressions are not related with PTEN inactivation in clear cell adenocarcinoma of the ovary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma, Clear Cell / metabolism*
  • Adult
  • Aged
  • Aged, 80 and over
  • Cyclin D1 / biosynthesis
  • Cyclin-Dependent Kinase Inhibitor p27 / biosynthesis
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Ovarian Neoplasms / metabolism*
  • PTEN Phosphohydrolase / biosynthesis*


  • Cyclin D1
  • Cyclin-Dependent Kinase Inhibitor p27
  • PTEN Phosphohydrolase
  • PTEN protein, human