Successful treatment of MRSA native valve endocarditis with oral linezolid therapy: a case report

J Infect. 2005 Nov;51(4):e213-5. doi: 10.1016/j.jinf.2005.02.016.

Abstract

Staphylococcal endocarditis is potentially fatal and is now the most common cause of infective endocarditis with a mortality rate of 25-47% [Hecht SR, Berger M. Right-sided endocarditis in intravenous drug users: prognostic features in 102 episodes. Ann Intern Med 1992;117:560-6]. Its treatment requires maintenance of bactericidal level of antibiotics for prolonged periods to attain a culture-negative state. Although intravenous vancomycin is currently the drug of choice for methicillin resistant Staphylococcus aureus (MRSA) endocarditis, we present a case treated successfully with oral linezolid for 4 weeks due to a lack of venous access.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / administration & dosage*
  • Administration, Oral
  • Adult
  • Anti-Infective Agents / administration & dosage*
  • Asthma / complications
  • Echocardiography / methods
  • Endocarditis, Bacterial / diagnostic imaging
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / microbiology
  • Female
  • Humans
  • Linezolid
  • Methicillin Resistance*
  • Oxazolidinones / administration & dosage*
  • Staphylococcal Infections / complications
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / isolation & purification

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid