Abstract
We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Biofilms / growth & development*
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Culture Media
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Gene Expression Regulation, Bacterial
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Iron*
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Mutation
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Staphylococcus aureus / genetics
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Staphylococcus aureus / physiology*
Substances
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Bacterial Proteins
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Culture Media
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Repressor Proteins
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ferric uptake regulating proteins, bacterial
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Iron