Iron-responsive regulation of biofilm formation in staphylococcus aureus involves fur-dependent and fur-independent mechanisms

J Bacteriol. 2005 Dec;187(23):8211-5. doi: 10.1128/JB.187.23.8211-8215.2005.

Abstract

We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Biofilms / growth & development*
  • Culture Media
  • Gene Expression Regulation, Bacterial
  • Iron*
  • Mutation
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / physiology*

Substances

  • Bacterial Proteins
  • Culture Media
  • Repressor Proteins
  • ferric uptake regulating proteins, bacterial
  • Iron