Ganciclovir implant in the treatment of cytomegalovirus retinitis

Expert Rev Med Devices. 2005 Jul;2(4):421-7. doi: 10.1586/17434440.2.4.421.

Abstract

The ganciclovir implant is a sustained-release intraocular drug delivery system used to treat cytomegalovirus retinitis that provides a high and steady-state concentration of the drug in the vitreous cavity over a period of 7-8 months. Randomized, controlled clinical trials have demonstrated a superior efficacy of the implant compared with intravenous ganciclovir. Severe adverse events associated with the implant are uncommon, though potentially blinding. In addition, the implant provides no protection against second-eye or visceral cytomegalovirus retinitis infections. This review summarizes the clinical indications for and complications associated with the ganciclovir implant.

Publication types

  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • Antiretroviral Therapy, Highly Active
  • Antiviral Agents / administration & dosage*
  • Antiviral Agents / adverse effects
  • Cytomegalovirus Retinitis / drug therapy*
  • Drug Implants / administration & dosage
  • Drug Implants / adverse effects
  • Ganciclovir / administration & dosage*
  • Ganciclovir / adverse effects
  • Humans

Substances

  • Antiviral Agents
  • Drug Implants
  • Ganciclovir