Comparison of ICG-assisted ILM peeling and triamcinolone-assisted posterior vitreous removal in diffuse diabetic macular oedema

Eye (Lond). 2006 Dec;20(12):1357-9. doi: 10.1038/sj.eye.6702152. Epub 2005 Nov 18.


Aim: To compare the effect of indocyanine green (ICG)-assisted internal limiting membrane (ILM) peeling and triamcinolone acetonide-assisted posterior vitreous removal on visual acuity in patients with diffuse diabetic macular oedema (DMO).

Methods: In total, 24 patients with diffuse DMO who underwent pars plana vitrectomy were included in this study. In all, 11 patients (mean age 57 years) were performed ICG-assisted ILM peeling; while 13 patients (mean age 54 years) underwent triamcinolone-assisted posterior vitreous removal. Patients from two different treatment regimens were compared in terms of best-corrected visual acuity (BCVA) at postoperative sixth months.

Results: In ICG-assisted ILM peeling group, preoperative BCVA (1.3+/-0.4, mean+/-SD, logMAR) improved postoperatively to 0.9+/-0.5 (P=0.011). In eyes underwent triamcinolone-assisted posterior vitreous removal, baseline BCVA of 1.4+/-0.4 improved to 1.0+/-0.5 (P=0.007). There was no difference between baseline as well as postoperative sixth-month BCVA results of both groups (P=0.59 and P=0.57, respectively).

Conclusions: Triamcinolone-assisted posterior vitreous removal and ICG-assisted ILM peeling have the same effect in terms of postoperative BCVA in patients with diffuse DMO.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetes Mellitus, Type 2 / surgery*
  • Diabetic Retinopathy / physiopathology
  • Diabetic Retinopathy / surgery*
  • Epiretinal Membrane / surgery*
  • Female
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • Humans
  • Indocyanine Green
  • Light Coagulation
  • Macular Degeneration / physiopathology
  • Macular Degeneration / surgery*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Statistics, Nonparametric
  • Treatment Outcome
  • Triamcinolone Acetonide / therapeutic use
  • Visual Acuity
  • Vitrectomy*


  • Glucocorticoids
  • Triamcinolone Acetonide
  • Indocyanine Green