Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera

Bioorg Med Chem Lett. 2006 Feb 15;16(4):949-53. doi: 10.1016/j.bmcl.2005.10.096. Epub 2005 Nov 15.

Abstract

Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera. Their structures were determined by X-ray crystallographic diffraction analysis and extensive 1D, 2D NMR spectroscopic data. Both of them evidently showed antioxidant activity against superoxide and hydroxyl radicals. Only 1 obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Antioxidants* / chemistry
  • Antioxidants* / isolation & purification
  • Antioxidants* / pharmacology
  • Coumarins* / chemistry
  • Coumarins* / isolation & purification
  • Coumarins* / pharmacology
  • Crystallography, X-Ray
  • Immunologic Factors* / chemistry
  • Immunologic Factors* / isolation & purification
  • Immunologic Factors* / pharmacology
  • Macrophage Activation / drug effects
  • Macrophages, Peritoneal / drug effects
  • Macrophages, Peritoneal / physiology
  • Magnetic Resonance Spectroscopy / methods
  • Magnetic Resonance Spectroscopy / standards
  • Models, Molecular
  • Molecular Conformation
  • Reference Standards
  • Stereoisomerism
  • Superoxides / metabolism

Substances

  • Antioxidants
  • Coumarins
  • Immunologic Factors
  • Superoxides