Reactive arthritis

Infect Dis Clin North Am. 2005 Dec;19(4):863-83. doi: 10.1016/j.idc.2005.07.001.


ReA consists of sterile axial or peripheral articular inflammation,enthesitis, and extra-articular manifestations. Most patients are HLA-B27 positive, although determining the B27 status of an individual patient is irrelevant. Exposure to specific bacterial antigens is usually the inciting factor. Diagnosis usually can be made by clinical examination and history. The current standard therapy is NSAIDs and physiotherapy, but molecular biologic treatment may ultimately become the mainstay in recalcitrant and severe ReA.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis, Reactive* / diagnosis
  • Arthritis, Reactive* / drug therapy
  • Arthritis, Reactive* / etiology
  • Arthritis, Reactive* / physiopathology
  • Bacterial Infections / complications
  • Diagnosis, Differential
  • Humans
  • Prohibitins


  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • PHB2 protein, human
  • Prohibitins