Mesenchymal stem cells for bone repair: preclinical studies and potential orthopedic applications

Foot Ankle Clin. 2005 Dec;10(4):651-65, viii. doi: 10.1016/j.fcl.2005.06.004.


Mesenchymal stem cells (MSCs), derived from adult bone marrow, are multi-potent stem cells capable of differentiating along several lineage pathways. From a small bone marrow aspirate, MSCs can be readily isolated and easily expanded. Therefore, MSCs are thought to be a readily available source of cells for many tissue engineering and regenerative medicine applications. This review covers preclinical models that evaluate the efficacy of MSC-loaded scaffolds in large bone defects as a potential substitute for autologous and allogeneic bone grafts. This review also covers new approaches to clinical use of MSC technology.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Bone Diseases / physiopathology
  • Bone Diseases / surgery*
  • Bone Regeneration / physiology
  • Humans
  • Mesenchymal Stem Cell Transplantation / methods*
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / physiology
  • Orthopedic Procedures / methods
  • Osteogenesis / physiology
  • Tissue Engineering / methods*