An update on the classification and treatment of vasculitic neuropathy

Lancet Neurol. 2005 Dec;4(12):853-65. doi: 10.1016/S1474-4422(05)70249-0.


Vasculitic neuropathy usually presents with painful mononeuropathies or an asymmetric polyneuropathy of acute or subacute onset. The disorder should be classified as being systemic or non-systemic. Systemic vasculitis should be further classified into one of the primary and secondary forms. Although specific treatment regimens vary among neurologists, basic principles can be applied. Corticosteroids and cytotoxic drugs have been the mainstay of treatment for most forms of vasculitic neuropathy. Here we discuss dosing, potential side-effects, and management recommendations of conventional treatments. New treatments showing promise include intravenous immunoglobulin and biological agents and trials of the newest treatments are being reviewed. Future trials should compare commonly used treatment regimens and better establish the efficacy of newer, potentially safer, treatments.

Publication types

  • Review

MeSH terms

  • Humans
  • Polyneuropathies / classification*
  • Polyneuropathies / pathology
  • Polyneuropathies / therapy*
  • Therapeutics
  • Vasculitis / classification*
  • Vasculitis / pathology
  • Vasculitis / therapy*