Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease

Neurobiol Aging. 2006 Jan;27(1):10-5. doi: 10.1016/j.neurobiolaging.2004.12.003.


To study the potential diagnostic value of abnormally phosphorylated tau protein in Creutzfeldt-Jakob disease (CJD) compared to Alzheimer's disease (AD), we determined levels of tau phosphorylated at threonine 231 (p-tau231) and of total tau (t-tau) in cerebrospinal fluid (CSF) of CJD patients, AD patients, and healthy controls (HC). CJD patients showed excessively high t-tau levels but relatively low p-tau(231) concentrations compared to the AD group. t-tau alone yielded the best diagnostic accuracy to differentiate between CJD and AD patients, when compared to p-tau231 and the p-tau231/t-tau ratio (97, 78, and 95% correctly allocated cases, respectively). Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Aged
  • Alzheimer Disease / cerebrospinal fluid*
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / epidemiology
  • Biomarkers / cerebrospinal fluid
  • Creutzfeldt-Jakob Syndrome / cerebrospinal fluid*
  • Creutzfeldt-Jakob Syndrome / diagnosis*
  • Creutzfeldt-Jakob Syndrome / epidemiology
  • Diagnosis, Differential
  • Female
  • Germany / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Phosphorylation
  • Prevalence
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sex Distribution
  • Statistics as Topic
  • Threonine / metabolism*
  • tau Proteins / cerebrospinal fluid*


  • Biomarkers
  • tau Proteins
  • Threonine