Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

J Med Virol. 2006 Jan;78(1):1-8. doi: 10.1002/jmv.20499.

Abstract

Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology*
  • Coronavirus Nucleocapsid Proteins
  • Disease Progression
  • Humans
  • Membrane Glycoproteins / immunology
  • Neutralization Tests
  • Nucleocapsid Proteins / immunology
  • SARS Virus / immunology*
  • Severe Acute Respiratory Syndrome / immunology*
  • Severe Acute Respiratory Syndrome / physiopathology
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins / immunology

Substances

  • Antibodies, Viral
  • Coronavirus Nucleocapsid Proteins
  • Membrane Glycoproteins
  • Nucleocapsid Proteins
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins
  • spike glycoprotein, SARS-CoV