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. 2006 Feb 15;16(4):854-8.
doi: 10.1016/j.bmcl.2005.11.015. Epub 2005 Nov 21.

Substituted 4-hydroxyphenyl Sulfonamides as Pathway-Selective Estrogen Receptor Ligands

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Substituted 4-hydroxyphenyl Sulfonamides as Pathway-Selective Estrogen Receptor Ligands

Joseph P Sabatucci et al. Bioorg Med Chem Lett. .

Abstract

The transcription factor nuclear factor-kappaB (NF-kappaB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-kappaB transcriptional activity but are devoid of conventional estrogenic activity.

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