Hypoglycemia: a complication of diabetes therapy in children

Pediatr Clin North Am. 2005 Dec;52(6):1705-33. doi: 10.1016/j.pcl.2005.08.002.


The experience of hypoglycemia is probably the most feared and hated consequence of life with type 1 diabetes among pediatric patients and their parents. Although transient detrimental effects are clearly disturbing and may have severe results, there is surprisingly little evidence of long-term CNS damage, even after multiple hypoglycemic episodes, except in rare instances. Despite the latter evidence, we advocate that every treatment regimen be designed to prevent hypoglycemia without inducing unacceptable hyperglycemia and increasing the risk of micro- and macrovascular complications.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Blood Glucose / metabolism
  • Brain / physiopathology
  • Child
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / physiopathology*
  • Diabetes Mellitus / therapy
  • Electroencephalography
  • Humans
  • Hypoglycemia / blood
  • Hypoglycemia / physiopathology*
  • Hypoglycemia / therapy
  • Prognosis
  • Recurrence
  • Risk Factors


  • Blood Glucose